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The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Episode 15350:12:05What 36 Hours Without Sugar Does to Your Body : 1535
This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements.
Episode 15340:09:48New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534
This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat.
Episode 15331:09:00Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533
Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.
Episode 15320:10:03If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532
Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.
Episode 15310:07:48Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531
This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.
Episode 15301:58:16Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530
Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.
Episode 15290:35:543 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529
Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.
Episode 15280:09:437 Brain Compounds I Take For Superhuman Focus : 1528
can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll also learn" section based on this episode's content: You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties Want me to add this to the script, or adjust the tone or number of bullets? give me a dash in front of each bullet You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties can you give me timestamps for this episode. similar to this previous example: Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Timestamps: 00:00 – Intro & The Brain Fog Problem 01:12 – Fixing Brain Energy 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 now i need a one sentence summary of this episode After overcoming his own brain fog, the creator breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance.
Episode 15271:13:33Change Your Morning, Change Your Life! Hal Elrod : 1527
Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.
Episode 15261:01:46Learn THIS And You’ll Become Impossible To Trigger : 1526
Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity.
Episode 15251:01:59Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525
Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.
Episode 15240:14:42The Most Important Longevity Molecule I've Ever Found : 1524
Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.